人物經曆
1988-6/1992 北京大學 學士
1994-1/2000 美國羅格斯大學 (Rutgers University) 博士
2000 - 2/2000 美國羅格斯大學 (Rutgers University) 博士後
2000 - 8/2004 美國 Tularik 公司，科學家 , 助理科學家 , 資深研究助理
2004 - 10/2005 美國 Amgen 公司，資深科學家
2005 - 現在 中國科學院廣州生物醫藥與健康研究院，研究員
主要成就
科研成就
承擔科研項目情況：
1. 國家重點研發計劃（2017年），項目負責人。
3. 國家自然科學基金面上項目（2018年、2016年、2012年、2009年），項目負責人。
4. 國家自然科學基金聯合基金項目（2013年），項目負責人。
5. 廣東省自然科學基金團隊項目（2015），項目負責人。
6. 廣州市健康醫療協同創新重大專項（2014），項目負責人。
代表論著：
1. Xu T.*, Gan Q., Wu B., Yin M., Xu J., Shu X., Liu J.*. Molecular Basis for PI(3,5)P2 Recognition by SNX11, a Protein Involved in Lysosomal Degradation and Endosome Homeostasis Regulation. J Mol Biol 2020, 432(16): 4750-4761.
2. Xu J.#*, Tang X.#, Zhu Y., Yu Z., Su K., Zhang Y., Dong Y., Zhu W., Zhang C., Wu R., Liu J.*. Structural studies reveal flexible roof of active site responsible for omega-transaminase CrmG overcoming by-product inhibition. Commun Biol 2020, 3(1): 455.
3. Makafe, G. G.#, Hussain, M.#, Surineni, G., Tan, Y., Wong, N. K., Julius, M., Liu, L., Gift, C., Jiang, H., Tang, Y., Liu, J., Tan, S., Yu, Z., Liu, Z., Lu, Z., Fang, C., Zhou, Y., Zhang, J., Zhu, Q., Liu, J.* and Zhang, T.* Quinoline Derivatives Kill Mycobacterium tuberculosis by Activating Glutamate Kinase. Cell Chem Biol 2019, 26, 1187-1194 e1185
4. Hussain, M.#, Adah, D.#, Tariq, M., Lu, Y., Zhang, J.* and Liu, J.* CXCL13/CXCR5 signaling axis in cancer. Life Sci 2019, 227, 175-186
5. Xu T, Zhou CZ, Xiao J.*, Liu J.* Unique Conformation in a Natural Interruption Sequence of Type XIX Collagen Revealed by Its High-Resolution Crystal Structure. Biochemistry 2018, 57(7): 1087-1095
6. Wang N, Zou Q, Xu J, Zhang J, Liu J.* Ligand binding and heterodimerization with retinoid X receptor alpha (RXRalpha) induce farnesoid X receptor (FXR) conformational changes affecting coactivator binding. The journal of biological chemistry 2018, 293(47): 18180-18191
7. Xu T., Xie C., Yao D., Zhou CZ., Liu J.*. Crystal structures of Aflatoxin-oxidase from Armillariella tabescens reveal a dual activity enzyme. Biochemical and biophysical research communications 2017, 494(3-4): 621-625
8. Xu J#, Zhang L#, Ye Y, Shan Y, Wan C, Wang J, Pei D, Shu X.*, Liu J.* SNX16 Regulates the Recycling of E-Cadherin through a Unique Mechanism of Coordinated Membrane and Cargo Binding. Structure 2017, 25(8): 1251-1263 e1255
9. Hou S, Xu T, Xu J, Qu L, Xu Y, Chen L, Liu J*. Structural basis for functional selectivity and ligand recognition revealed by crystal structures of human secreted phospholipase A2 group IIE. Scientific reports 2017, 7(1): 10815
10. Zhu Y#, Xu J#, Mei X#, Feng Z, Zhang L, Zhang Q, Zhang G, Zhu W*, Liu J*, Zhang C*. Biochemical and Structural Insights into the Aminotransferase CrmG in Caerulomycin Biosynthesis. ACS chemical biology 2016, 11(4): 943-952
11. Hussain M, Lu Y, Liu YQ, Su K, Zhang J, Liu J*, Zhou GB*. Skp1: Implications in cancer and SCF-oriented anti-cancer drug discovery. Pharmacological research 2016, 111: 34-42
12. Zhu L, Yang J, Li H, Sun H, Liu J*, Wang J*. Conformational change study of dengue virus NS2B-NS3 protease using (19)F NMR spectroscopy. Biochemical and biophysical research communications 2015, 461(4): 677-680
13. Liu YQ#, Wang XL#, Cheng X#, Lu YZ#, Wang GZ#, Li XC, Zhang J, Wen ZS, Huang ZL, Gao QL, Yang LN, Cheng YX*, Tao SC, Liu J *, Zhou GB*. Skp1 in lung cancer: clinical significance and therapeutic efficacy of its small molecule inhibitors. Oncotarget 2015, 6(33): 34953-34967
14. Guo S#, Xu J#, Pavlidis IV, Lan D, Bornscheuer UT, Liu J*, Wang Y*. Structure of product-bound SMG1 lipase: active site gating implications. The FEBS journal 2015, 282(23), 4538-4547
15. Xu T, Xu J, Ye Y, Wang Q, Shu X, Pei D, Liu J*. Structure of human SNX10 reveals insights into its role in human autosomal recessive osteopetrosis. Proteins 2014, 82(12): 3483-3489
16. Mei G, Dong J, Li Z, Liu S, Liu Y, Sun M, Liu G, Su Z*, Liu J*. Structural basis for the immunomodulatory function of cysteine protease inhibitor from human roundworm Ascaris lumbricoides. PloS one 2014, 9(4): e96069
17. Li H, Zhu L, Hou S, Yang J, Wang J*, Liu J*. An inhibition model of BPTI to unlinked dengue virus NS2B-NS3 protease. FEBS letters 2014, 588(17): 2794-2799
18. Xu J, Xu T, Wu B, Ye Y, You X, Shu X, Pei D, Liu J*. Structure of sorting nexin 11 (SNX11) reveals a novel extended phox homology (PX) domain critical for inhibition of SNX10-induced vacuolation. The Journal of biological chemistry 2013, 288(23): 16598-16605
19. Xu T#, Liu L#, Hou S, Xu J, Yang B, Wang Y*, Liu J*. Crystal structure of a mono- and diacylglycerol lipase from Malassezia globosa reveals a novel lid conformation and insights into the substrate specificity. J Struct Biol 2012, 178(3): 363-369
20. Liu J#, Sudom A#, Min X#, Cao Z, Gao X, Ayres M, Lee F, Cao P, Johnstone S, Plotnikova O, Walker N, Chen G, Wang Z. Structure of the nuclear factor kappaB-inducing kinase (NIK) kinase domain reveals a constitutively active conformation. The Journal of biological chemistry 2012, 287(33): 27326-27334
21. Bi Y, Zhu L, Li H, Wu B, Liu J*, Wang J*. Backbone (1)H, (13)C and (15)N resonance assignments of dengue virus NS2B-NS3p in complex with aprotinin. Biomol NMR Assign 2012, 7:137-139
22. Zhang Y, Xu T, Chen Q, Wang B, Liu J*. expression, purification, and refolding of active human and mouse secreted group IIE phospholipase A. Protein Expr Purif 2011, 80(1): 68-73
23. Wang Y, Wang Q, Zhu Q, Zhou R, Liu J*, Peng T*. Identification and characterization of acyclovir-resistant clinical HSV-1 isolates from children. J Clin Virol 2011, 52(2): 107-112
24. Lu N, Wang W, Liu J*, Wong CW*. Protein kinase C epsilon affects mitochondrial function through estrogen-related receptor alpha. Cell Signal 2011, 23(9): 1473-1478
25. Liu S, Dong J, Mei G, Liu G, Xu W, Su Z, Liu J*. Crystallization and preliminary crystallographic studies of a cysteine protease inhibitor from the human nematode parasite Ascaris lumbricoides. Acta Crystallogr Sect F Struct Biol Cryst Commun 2011, 67(Pt 2): 228-230
26. Liu Q, Shen Y, Liu S, Weng J, Liu J*. Crystal structure of E339K mutated human glucokinase reveals changes in the ATP binding site. FEBS letters 2011, 585(8): 1175-1179
27. Gong L, Xiao Y, Liu Q, Li S, Zhang C, Liu J*. Preliminary X-ray crystallographic analysis of the glycosyltransferase from a marine Streptomyces species. Acta Crystallogr Sect F Struct Biol Cryst Commun 2011, 67(Pt 1): 136-139
28. Gao M#, Wang J#, Lu N#, Fang F, Liu J*, Wong CW*. Mitogen-activated protein kinase kinases promote mitochondrial biogenesis in part through inducing peroxisome proliferator-activated receptor gamma coactivator-1beta expression. Biochimica et biophysica acta 2011, 1813(6): 1239-1244
29. Xu W#, Yi L#, Feng Y, Chen L*, Liu J*. Structural insight into the activation mechanism of human pancreatic prophospholipase A2. The Journal of biological chemistry 2009, 284(24): 16659-16666.
30. Bella J#, Liu J#, Kramer R, Brodsky B, Berman HM*. Conformational effects of gly-x-gly interruptions in the collagen triple helix. J Mol Biol 2006, 362(2): 298-311.
30. Wang Z#, Benoit G#, Liu J, Prasad S, Aarnisalo P, Liu X, Xu H, Walker NP*, Perlmann T*. Structure and function of Nurr1 identifies a class of ligand-independent nuclear receptors. Nature 2003, 423(6939): 555-560.
31. Benoff B, Yang H, Lawson CL, Parkinson G, Liu J, Blatter E, Ebright YW, Berman HM*, Ebright RH*. Structural basis of transcription activation: the CAP-alpha CTD-DNA complex. Science 2002, 297(5586): 1562-1566.
32. Liu J, Lynch PA, Chien CY, Montelione GT, Krug RM, Berman HM*. Crystal structure of the unique RNA-binding domain of the influenza virus NS1 protein. Nat Struct Biol 1997, 4(11): 896-899.
社會任職
呼吸疾病國家重點實驗室 副主任
廣東省生物醫藥計算重點實驗室 副主任
